Detail Cantuman

ABSTRAK

Latar belakang : Aloimunisasi dan autoimunisasi sel darah merah tetap menjadi masalah utama pada pasien thalasemia yang bergantung pada transfusi.
Tujuan : Untuk mengetahui identifikasi antibodi pada pasien thalasemia yang di rujuk ke laboratorium UDD PMI DKI Jakarta.
Metode : Penelitian ini merupakan penelitian yang bersifat deskriptif dengan rancangan penelitian cross sectional, yaitu pengukuran variable dilakukan dalam waktu bersamaan. Data diperoleh dari data sekunder hasil pemeriksaan lanjutan identifikasi antibodi pasien thalasemia di laboratorium rujukan UDD PMI DKI Jakarta dan diperoleh sampel sebanyak 100 pasien. Data dianalisis secara deskriptif dalam bentuk tabel.
Hasil : Dalam penelitian menunjukkan bahwa terdapat 77 pasien (77 %) yang terdeteksi memiliki antibodi ireguler, mayoritas perempuan 44 (57 %), pada kelompok usia ≤ 20 tahun sebanyak 42 pasien (55 %), dan mayoritas pasien golongan darah O Rh positif 26 (33,77 %). Spesifisitas antibodi yang terdeteksi masih banyak yang belum dapat ditentukan 52 (67,53 %), sedangkan yang spesifik porporsi terbesar adalah anti – E 14 (18,18 %), 1 sampel (1,30 %) pada masing – masing anti – c, anti – M, anti - Miª, anti - Jkª, anti - Jkᵇ, dan anti – S; dan pada multiantibodi terdapat 4 sampel anti – E dan anti – c (5,19 %); dan 1 sampel anti - Miª dan anti – E (1,30 %).
Kesimpulan : Antibodi ireguler yang ditemukan pada plasma pasien thalasemia di Unit Donor Darah Palang Merah Indonesia Daerah Khusus Ibokota Jakarta adalah anti-E, anti-c, anti-M, anti - Miª, anti - Jkª, anti - Jkᵇ, dan anti – S. Sedangkan plasma yang mengandung multiantibodi adalah (anti-E dan anti-c) dan (anti - Miª dan anti – E).
Kata kunci : Identifikasi antibodi, Thalasemia

ABSTRACT

Background: Alloimmunization and autoimmunization of red blood cells remains a major problem in transfusion-dependent thalassemia patients.
Purpose: To determine the identification of antibodies in thalassemia patients referred to the UDD PMI DKI Jakarta laboratory.
Methods: This study was a descriptive study with a cross sectional design, in which the variables were measured at the same time. Data obtained from secondary data from the results of further examination of identification of thalassemia patient antibodies in the referral laboratory of the UDD PMI DKI Jakarta and obtained a sample of 100 patients. Data were analyzed descriptively in tabular form.
Results: The study showed that there were 77 patients (77%) who were detected to have irregular antibodies, the majority of women were 44 (57%), 42 patients (55%) were ≤ 20 years old, and the majority of patients were blood type O Rh positive 26 (33.77%). The specificity of the antibodies that were detected was still undetermined 52 (67.53%), while the highest specific proportion was anti-E 14 (18.18%), 1 sample (1.30%) for each anti-c. , anti - M, anti - Miª, anti - Jkª, anti - Jkᵇ, and anti - S; and in multiantibodies there were 4 samples of anti-E and anti-c (5.19%); and 1 sample for anti - Miª and anti - E (1.30%).
Conclusion: The irregular antibodies found in the plasma of thalassemia patients in the Blood Donation Unit of the Indonesian Red Cross, the Jakarta Capital City Special Region, are anti-E, anti-c, anti-M, anti-Miª, anti-Jkª, anti-Jkᵇ, and anti-S Meanwhile, the plasma containing multiantibodies is (anti-E and anti-c) and (anti-Miª and anti-E).
Keywords: Identification of antibodies, Thalassemi.